Endocrine Abstracts

Introduction: Insulin resistance is classically a feature of type 2 diabetes mellitus (T2D). It may also develop among patients with type 1 diabetes (T1D) increasing the risk of cardiovascular mortality. Metabolic syndrome (MS) reflects a state of IR. The aim of this study was to assess the frequency of MS in a population of young adults with T1D and compare it to healthy controls.Methods: We conducted a case control study including 68 T1D patients and 6...

Introduction: Patients with Sheehan’s syndrome (SS) may experience alterations in blood pressure (BP) regulation, possibly due to hormones deficiencies and hormone replacement treatment. The aim of the present study was to assess the 24h ambulatory BP in women with Sheehan syndrome.Methods: This was a monocentric cross-sectional study involving 50 women with complete anterior hypopituitarism secondary to SS and 50 age and body-mass index (BMI) match...

Introduction: Non-functioning adrenal incidentaloma (NFAI) is a frequently diagnosed since the increased use of radiological examinations. The recent studies have shown that NFAI might have negative cardiometabolic effects and increased cardiovascular risk. The aim of this case control study was to determine the relationship between NFAI, CRP-hs, uric acid and cardiovascular risk (CVR) based on GLOBORISK algorithm of Tunisia.Methods: This case-control st...

Introduction: Vitamin D deficiency is an emerging concern that has the potential to impact one’s health, even in sunny Mediterranean countries like Tunisia. This issue is particularly notable among indoor workers in the healthcare sector, who experience minimal sun exposure. The aim of this study was to describe the Vitamin D profile within this specific population and to establish its association with lipid parameters.Methods: This cross-sectional ...

Introduction: The prevalence of metabolic syndrome (MS) is constantly increasing, particularly among young individuals with sedentary professions. Identifying individuals with MS is crucial for implementing personalized interventions to prevent cardiovascular events. Our study aimed to assess the metabolic profile of young and healthy healthcare professionals, considering the specific lifestyle linked with their professional roles.Methods: This cross-sec...

Introduction: DiGeorge syndrome (DGS) is mainly characterized by congenital heart defects, dysmorphic features, hopolasia of the thymus and parathyroid glands and immunodeficiency. Approximately 10% of patients with DGS have autoimmune disease1. Observation: This is a 21-year-old patient, diagnosed with DGS at the age of 14 year old. The diagnosis was suspected on the association of characteristic facial, hypoparathyroidism and a congenital he...

Introduction: Insulinomas are rare pancreatic endocrine tumors causing severe hypoglycemia in non-diabetic patients. We report a case of a rare association between insulinoma and type 2 diabetes.Presentation of the case: A 65-year-old diabetic patient presented with a one year history of recurrent hypoglycemia even after the withdrawal of antidiabetic drugs. First, a functional hypoglycemia was suspected and an oral glucose tolerance test showed hypoglyc...

Introduction: Sheehan’s syndrome is a rare cause of hypopituitarism. It is defined by an ischemic necrosis of the pituitary gland following postpartum hemorrhage. Sheehan syndrome is characterized by various endocrine deficiencies. The aim of the present study was to determine the clinical and paraclinical characteristics of women with Sheehan syndrome.Methods: This was a monocentric cross-sectional study including 50 women followed for Sheehan&#146...

Introduction: Antithyroid drugs are the firstline medical treatment for hyperthyroidism in addition to symptomatic treatment (rest, beta-blockers). The most widely used in Tunisia is Thiamazole. They are generally well tolerated, but side effects have been reported. The most serious ones are agranulocytosis and liver damage. Allergic skin reactions (pruritus, urticaria) are the most common. We herein report a case of a lichenoid dermatitis bullous toxidermia induced by Thiamaz...

Introduction: Hashimoto’s thyroiditis is the most frequent cause of hypothyroidism with a relative increased risk of thyroid lymphoma compared to healthy subjects. Hyperfunctioning nodules are rarely malignant. We report the case of a rare association of thyroid carcinoma, a hyperfunctioning nodule and Hashimoto thyroiditis.Observation: We report the case of a 40-year-old female patient treated with L-thyroxine for hypothyroidism due to Hashimoto th...